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Bibliography on: Urolithiasis

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Urolithiasis

Some mineral solutes precipitate to form crystals in urine; these crystals may aggregate and grow to macroscopic size, at which time they are known as uroliths (calculi or stones). Mechanisms involved in stone formation are incompletely understood in dogs and cats. Regardless of the underlying mechanism(s), uroliths are not produced unless sufficiently high urine concentrations of urolith-forming constituents exist and transit time of crystals within the urinary tract is prolonged. Clinical signs associated with urolithiasis are seldom caused by microscopic crystals. However, formation of macroscopic uroliths in the lower urinary tract that interfere with the flow of urine and/or irritate the mucosal surface often results in dysuria, hematuria, and stranguria. Urethral obstruction is common in male dogs and cats. It may occur suddenly or may develop throughout days or weeks. Initially, the animal may frequently attempt to urinate and produce only a fine stream, a few drops, or nothing. Animals may also exhibit extreme pain manifested by crying out when attempting to urinate. Complete obstruction causes uremia within 36–48 hr, which leads to depression, anorexia, vomiting, diarrhea, dehydration, coma, and death within ~72 hr.

NOTE: Urethral obstruction is an emergency condition, and treatment should begin immediately.

Created with PubMed® Query: ( (canine OR feline) AND (urolithiasis) ) NOT pmcbook NOT ispreviousversion

Citations The Papers (from PubMed®)

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RevDate: 2026-08-31

O'Malley B, Sadar MJ, Alexander AB, et al (2026)

Retrospective analysis of 68 domestic ferrets with urethral obstruction shows high rate of euthanasia at presentation despite good survival to discharge.

Journal of the American Veterinary Medical Association [Epub ahead of print].

OBJECTIVE: To establish a hospital proportional morbidity rate (HPMR) for urethral obstructions (UOs) in domestic ferrets; describe clinical presentation, interventions, and outcomes; and report associations with UO etiologies and survival.

METHODS: In this retrospective, descriptive, epidemiological study, electronic medical records were evaluated from ferrets presenting to 3 academic institutions in the US between 2013 and 2023. Descriptive and bivariate statistical analyses were performed. Parametric and nonparametric results are reported as mean ± SD or median (IQR).

RESULTS: A total of 3,242 records were reviewed. The HPMR was 2.09% (68 of 3,242). Urethral obstruction etiologies included urolithiasis (57.4% [39 of 68]), adrenal disease-associated prostatic disease (19.12% [13 of 68]), and undiagnosed etiology (23.53% [16 of 68]). Twenty-seven of 66 ferrets (40.91%) were euthanized on presentation. Of the remaining ferrets, 92.31% (36 of 39) survived to discharge. Average hospitalization time was 2.82 ± 2.21 days. Complications occurred in 23.08% (9 of 39) of ferrets, and recurrence rate after discharge was 31.6% (6 of 19) with a median of 19 days (IQR, 1 to 1,164 days). Ferrets with urolithiasis were significantly younger (median, 2 years old) and had significantly higher blood glucose (median, 127 mg/dL) compared to ferrets with adrenal disease-associated prostatic disease (median age, 5 years old; median blood glucose, 91 mg/dL). Ferrets that survived to discharge had significantly higher body temperature on admission (median, 37.4 °C [99.4 °F]) compared to ferrets that were euthanized (median, 36.7 °C [98 °F]).

CONCLUSIONS: Ferrets with UO had an HPMR, hospitalization times, and survival and recurrence rates that were similar to those of cats.

CLINICAL RELEVANCE: These findings provide objective prognostic data to better inform treatment recommendations and client decision-making.

RevDate: 2019-09-11
CmpDate: 1980-01-24

Lang F, Greger R, Sporer H, et al (1979)

Renal handling of urate and oxalate: possible implications for urolithiasis.

Urological research, 7(3):143-148.

Both urate and oxalate are organic acids of considerable clinical interest, owing to their limited solubility. Calcium oxalate is the most frequent constituent of renal calculi and occasionally precipitates in body fluids. Urate precipitations are common in the kidney and in various other tissues. In this paper, a short outline of the present knowledge of renal handling of these substances will be followed by some conclusions as to the possible relevance of this knowledge for the understanding of urolithiasis and intrarenal precipitation. Direct (micropuncture) data are available for urate in the rat (1, 6, 7, 10, 21, 23, 28, 36, 42), rabbit (35), dog (34) and cebus monkey (33) and in the rat only for oxalate (11, 15, 20).

RevDate: 2006-11-15
CmpDate: 1976-06-02

Legendre AM (1976)

Silica urolithiasis in a dog.

Journal of the American Veterinary Medical Association, 168(5):418-419.

RevDate: 2019-07-02
CmpDate: 1976-08-02

Povey C (1976)

Viral diseases of cats: current concepts.

The Veterinary record, 98(15):293-299.

RevDate: 2019-09-07
CmpDate: 1977-12-29

Brody RS, Thomson R, Sayer P, et al (1977)

Silicate renal calculi in Kenyan dogs.

The Journal of small animal practice, 18(8):523-528.

RevDate: 2006-11-15
CmpDate: 1978-01-27

Fabricant CG (1977)

Herpesvirus-induced urolithiasis in specific-pathogen-free male cats.

American journal of veterinary research, 38(11):1837-1842.

RevDate: 2009-11-11
CmpDate: 1978-05-17

Scott FW (1978)

Recent developments in feline disease research.

The Cornell veterinarian, 68 Suppl 7:151-157.

RevDate: 2016-11-23
CmpDate: 1979-01-26

Ryan CP, JJ Wolfer (1978)

Cystic calculi in four cats.

Veterinary medicine, small animal clinician : VM, SAC, 73(11):1414-1421.

RevDate: 2016-11-23
CmpDate: 1979-07-25

Bradley RL, RR Cortesi (1979)

Lower urinary obstruction due to cystic calculi in a female cat (a case report).

Veterinary medicine, small animal clinician : VM, SAC, 74(3):353-356.

RevDate: 2003-11-14
CmpDate: 1980-04-17

Ryan CP, JK Barnes (1979)

Nephrolithiasis in a cat with malignant lymphoma.

Veterinary medicine, small animal clinician : VM, SAC, 74(10):1487-1494.

RevDate: 2019-09-11
CmpDate: 1978-12-29

Eisenberger F, C Chaussy (1978)

Contact-free renal stone fragmentation with shock waves.

Urological research, 6(3):111.

RevDate: 2019-07-13
CmpDate: 1978-12-20

Raney AM (1978)

Electrohydraulic ureterolithotripsy. Preliminary report.

Urology, 12(3):284-285.

RevDate: 2016-11-23
CmpDate: 1977-08-25

Marberger M, Georgi M, Günther R, et al (1977)

[Intraluminal balloon occlusion of the renal artery: clinical applications and observations (author's transl)].

Der Urologe. Ausg. A, 16(3):146-153.

A method permitting percutaneous catheterization and temporary balloon occlusion of the human renal artery with a 5-F-Swan-Ganz-Catheter is presented. When properly performed, the arterial occlusion is reliable, low in complications, and less traumatizing to the vessel than external clamp occlusion. The technique was employed in 112 patients for occlusion of the renal artery prior to tumor nephrectomy, for attaining stop-flow conditions for improved nephrophlebography, for preventing the reflux of emboli at transarterial embolisation of inoperable kidney tumors, or, combined with simultaneous hypothermic perfusion via the second lumen of the catheter, in extensive kidney surgery necessitating ischemia. Particularly this last range of application offers new possibilities for in-situ surgery of the kidney, as it renders dissection of the renal pedicle and cumbersome surface cooling of the kidney unnecessary.

RevDate: 2019-07-02
CmpDate: 1977-10-14

Weaver AD, R Pillinger (1977)

Lower urinary tract pathogens in the dog and their sensitivity to chemotherapeutic agents.

The Veterinary record, 101(4):77-79.

Ninety-six urine samples were collected by a sterile technique from 75 dogs affected with urinary tract disease (cystitis, urolithiasis, prostatitis, etc) involving bacteruria. The infecting organisms were isolated and tested against sensitivity discs (penicillin G, streptomycin, chloramphenicol, tetracycline, sulphamethoxazole/trimethaprin and Sulphatriad). The commonest isolate was Escherichia coli, which was generally sensitive to several agents, though in eight cases it was resistant to all drugs. Next in order were Streptococcus faecalis, Staphylococcus epidermidis and Proteus spp. A double infection was present in 11 cases. Further data give a breakdown for sex and the clinical diagnosis, neither of which was related to any particular organism.

RevDate: 2019-08-23
CmpDate: 1977-12-29

Dreikorn K, Röhl L, H Heering (1977)

An experimental model for extracorporeal renal surgery: ex situ removal of artificially induced renal staghorn calculi in ambiothermia.

European urology, 3(5):303-306.

An experimental model for the evaluation of surgical techniques and preservation in extracorporeal surgery is described: staghorn calculi were induced in 15 dogs by the injection of methylmethacrylate into the renal pelvis. Removal of the calculi was carried out 3-4 weeks later on a workbench, using microsurgical techniques and ex situ radiographies. 15 min of warm ischaemic and 6 h of ambiothermic preservation were well tolerated as could be demonstrated by determination of the serum creatinine following autotransplantation and immediate contralateral nephrectomy.

RevDate: 2022-03-18
CmpDate: 1978-08-28

Yendt ER, M Cohanim (1978)

Prevention of calcium stones with thiazides.

Kidney international, 13(5):397-409.

On the basis of almost 15 years of experience with thiazide treatment in 346 patients with calcium stones, we believe that the following conclusions are justified: 1) Stone progression ceases in at least 90% of patients who take hydrochlorothiazide (50 mg, twice daily) on a regular basis. 2) A reduced dose of hydrochlorothiazide, i.e., 25 mg twice daily, appears to be effective in a significant proportion of patients. 3) Thiazides are effective in normocalciuric as well as hypercalciuric patients and in most patients with tubular ectasia (medullary sponge kidney). 4. Side effects necessitate discontinuation of thiazide treatment in approximately 7% of patients. The incidence and severity of side effects is reduced by initiating treatment with a small dose and by increasing the dose progressively until the full maintenance dose is achieved. A trial with a reduced dose is warranted in patients who are unable to tolerate the regular maintenance dose. 5) The therapeutic efficacy of thiazides in stone prevention cannot be accurately predicted by the degree of hypocalciuric response. Stone prevention may cease despite a minimal hypocalciuric response, whereas stone progression may occur when an adequate hypocalciuric response has taken place. 6) In addition to the hypocalciuric action, thiazides reduce urine oxalate excretion and increase urine zinc and (probably) magnesium; these effects probably contribute to the efficacy of this agent in stone prevention.

RevDate: 2019-07-02
CmpDate: 1978-09-29

Gaskell CJ (1978)

Urolithiasis in the dog and the cat.

The Veterinary record, 102(25):546-547.

RevDate: 2019-07-19
CmpDate: 1979-10-26

Wickham JE, Fernando AR, Hendry WF, et al (1978)

Inosine: clinical results of ischaemic renal surgery.

British journal of urology, 50(7):465-468.

Ten patients requiring ischaemic renal surgery for calculus or tumour were operated on with the kidney protected by perfusion with a room temperature solution of inosine. The warm ischaemic times ranged from 35 to 75 min (mean 57.1 min). Post-operative recovery was uneventful in all patients. No adverse cardiodynamic effects due to inosine were noted. There was only moderate transient depression in renal function as assessed by gamma camera renography and serum creatinine estimations. Three of the 10 patients have now been followed for over a year. The results with inosine perfusion are comparable to those obtained with hypothermic protection.

RevDate: 2013-11-21
CmpDate: 1979-06-11

Fischer CP, LP Sonda (3rd) (1979)

Cryoprecipitate: its use and effects in canine coagulum pyelolithotomy.

Investigative urology, 16(4):266-269.

A fibrin clot forming an extractable cast or "coagulum" of the pyelocalyceal system was developed and characterized using a blood product not previously described--single donor type specific cryoprecipitate. The physical properties of the cryoprecipitate coagulum were investigated and compared with other described formulations. Simulated coagulum pyelolithotomy was performed in vivo in 11 canine kidneys with no adverse effect upon creatinine clearance or anatomic integrity. The advantages of the cryoprecipitate are detailed and a new, simplified operative technique is described.

RevDate: 2016-11-23
CmpDate: 1979-07-28

Klausner JS, CA Osborne (1979)

Dissolution of a struvite nephrolith in a dog.

Journal of the American Veterinary Medical Association, 174(10):1100-1104.

A large radiodense calculus in the left renal pelvis of a 22-month-old, male Great Dane disappeared one month following surgical removal of two struvite (magnesium ammonium phosphate) calculi from the right renal pelvis. The dog's urine likely became undersaturated with struvite for a sufficient period to permit dissolution of the renal calculus. Several factors may have contributed to the decrease in urine struvite concentration, including eradication of a urease-producing Proteus sp from the urinary tract and induction of polydipsia and compensatory polyuria by oral administration of sodium chloride.

RevDate: 2006-11-15
CmpDate: 1979-08-29

Hill BL, RC Postlewaite (1979)

Urethral rupture in a bitch with urolithiasis.

Journal of the American Veterinary Medical Association, 174(2):170-171.

RevDate: 2016-11-23
CmpDate: 1979-08-16

O'Handley P, Carrig CB, R Walshaw (1979)

Renal and ureteral duplication in a dog.

Journal of the American Veterinary Medical Association, 174(5):484-487.

Duplication of a kidney and ureter in an 18-month-old male English Bulldog was demonstrated radiographically and was confirmed surgically. Urinary tract infection had been a problem for a year. Antimicrobial therapy resolved the clinical signs of urinary infection but did not eliminate bacteriuria.

RevDate: 2019-09-11
CmpDate: 1979-09-01

Lindsey D, Parker DA, Arganese T, et al (1979)

Modification by dipyrone (noramidopyrine methanesulphonate) of stone-induced ureteric hyperperistalsis in the dog.

Urological research, 7(1):13-17.

Implantation of a stone in the ureter of the dog by ureterotomy results in focal hyperperistalsis which is accentuated by administration of norepinephrine, and reduced by administration of phenoxybenzamine or isoproterenol. Administration of dipyrone reduces the hyperperistalsis, but this action does not appear to be that of either a beta-agonist of an alpha-antagonist.

RevDate: 2013-11-21
CmpDate: 1979-09-17

Arnbjerg J (1979)

[Clinical use of ketamine-xylazine for anaesthesia in the cat (author's transl)].

Nordisk veterinaermedicin, 31(4):145-154.

Based on experiences from anaesthesia of approximately 7000 cats in a four year period the effects of a combination of 20--25 mg/kg Ketamine and 0.5 mg/kg Xylazine given i/m are described. In the present study the Xylazine has been applied in considerably lower doses, compared with previous reports on these drugs, and this change has reduced the unwanted side effects, without at the same time reducing the effect on the muscular tension and the psychical disturbances induced by the Ketamine. Ketamine and Xylazine were given in one injection after being taken in the named sequence and mixed in the syringe. Indication for anaesthetizing the cats were, besides routine surgery in the out-patient clinic, operations of weakened animals for pyometra, foreign bodies, intestinal invaginations with and without resection, removal of abdominal tumors and urolithiasis. Animals with impared liver function were not anaesthetized with these drugs due to the important role of liver metabolism in their excretion. In spite of the fact that the corneal and laryngeal reflexes normally persist, the combination of the two drugs allowed surgery in these organs after application of local anaesthetics as an extra precaution. Premedication with atropine has not been used routinely, and still only very few cases of increased salivation or vomiting have been observed. Aspiration has not been a complication and in the whole material, only 3 deaths have occurred, none of them with a specific post mortem finding besides shock. In these 3 cases the patient died later than 45 minutes after the injection and after ended surgery. Side effects ascribed to phenomena of interaction have not been observed. One cat was anaesthetized a number of times during pregnancy without any effect on the cat or its kittens. It is concluded, that the Ketamine/Xylazine combination, when mixed as prescribed gives a very safe and pleasant narcosis, and that side effects are minimized, if the corneas are moistened with an ophthalmic ointment and the patient is allowed to recover in dark and quiet surroundings.

RevDate: 2019-09-02
CmpDate: 1979-11-28

Fukuda S, O Matsuoka (1979)

Cystic calculosis repeating in a beagle dog.

Nihon juigaku zasshi. The Japanese journal of veterinary science, 41(4):413-415.

RevDate: 2006-11-15
CmpDate: 1979-12-18

Konrad G, Ziegler M, Hüsler E, et al (1979)

[Electric shock waves crushing stones in the exposed kidney (author's transl)].

Der Urologe. Ausg. A, 18(5):289-293.

Highenergy shock waves can desintegrate human calculi of the kidney into fine fragments without direct contact. A closed reflector system which allows sterile contact with the exposed kidney is presented.

RevDate: 2019-09-02
CmpDate: 1980-05-23

Gotchev D, Moneva-Antonova L, I Mladenov (1979)

Polymeric pyelotomy (experimental studies).

International urology and nephrology, 11(4):279-288.

A non-toxic, soluble polymeric preparation MAG with controlled period of gelation was synthetized for the extraction of stones from the pyelocalyceal system during surgery for urolithiasis. With respect to toughness the preparation proved superior to the fibrinogen-thrombin mixture, used in the so-called "fibrin pyelotomy" according to Dees. Its biologic testing in animals (rabbits, dogs and pigs) yielded excellent results.

RevDate: 2019-08-17
CmpDate: 1977-06-30

Watanabe H, S Oinuma (1977)

[Studies on the application of microexplosion to medicine and biology. I. Development of special explosive for the experiments (author's transl)].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 68(3):243-248.

RevDate: 2022-04-08
CmpDate: 1978-05-20

Tan RJ, EW Lim (1977)

Isolation of Torulopsis glabrata from a urine specimen of a Labrador bitch with urolithiasis.

The British veterinary journal, 133(3):324-325.

RevDate: 2006-11-15
CmpDate: 1979-03-24

Röcken H (1979)

[Urethrotomy in the bitch with an incarcerated urinary calculus].

Berliner und Munchener tierarztliche Wochenschrift, 92(2):26-27.

RevDate: 2013-11-21
CmpDate: 1977-06-11

Donovan CA (1977)

Clinical observations on use of methylene blue for urinary calculi and conception.

Veterinary medicine, small animal clinician : VM, SAC, 72(4):582.

RevDate: 2013-11-21
CmpDate: 1977-09-17

Kirkpatrick RM (1977)

Urate calculus in a male cat.

Veterinary medicine, small animal clinician : VM, SAC, 72(7):1171-1173.

RevDate: 2003-11-14
CmpDate: 1978-03-29

Irvine-Smith B (1977)

Perineal urethrostomy in the male cat.

Journal of the South African Veterinary Association, 48(4):282-283.

RevDate: 2009-11-11
CmpDate: 1978-04-17

Kaminski JM, Katz AR, SC Woodward (1978)

Urinary bladder calculus formation on sutures in rabbits, cats and dogs.

Surgery, gynecology & obstetrics, 146(3):353-357.

Cystotomies were performed upon 152 animals with various suture materials. The bladders were examined for the presence of concretions at intervals ranging from three to 120 days. Calculi were found with regularity in rabbits but not in cats or dogs, irrespective of the suture material used. Urinary calculi persisting later than seven days postoperatively were seen only in those rabbit bladders repaired with nonabsorbable sutures. Despite major differences in the geometry and chemical composition of the suture, the two absorbable sutures polyglycolic acid and catgut showed an equivalent incidence of early, reversible calculus formation in the rabbit urinary bladder. The property of suture materials that contributes most to the formation of persistent urinary calculi is nonabsorbability. Surface characteristics and cross sectional geometry appear to play little, or no, role in the calculus formation in the bladders of animals.

RevDate: 2016-11-23
CmpDate: 1978-04-26

Ryan CP (1978)

Nephrolithiasis in a cat.

Journal of the American Veterinary Medical Association, 172(2):162-164.

RevDate: 2019-09-18
CmpDate: 1978-07-26

Duch DS, Hamar DW, Chow FC, et al (1978)

Study on urine polyelectrolytes of cats with natural and experimental urolithiasis.

Biochemical medicine, 19(2):236-245.

RevDate: 2019-09-07
CmpDate: 1978-09-29

Gaskell CJ, Denny HR, Jackson OF, et al (1978)

Clinical management of the feline urological syndrome.

The Journal of small animal practice, 19(6):301-314.

RevDate: 2019-07-18
CmpDate: 1978-10-27

McIntosh GH (1978)

Urolithiasis in animals.

Australian veterinary journal, 54(6):267-271.

Urolithiasis is a disease of multifactorial origin. Prominent amongst the causes of disease outbreaks are nutritional factors. Alteration of diet is probably one of the most effective means of prevention, depending of course on the nature of the uroliths formed. In this regard analysis of the stones formed is an essential prelude to understanding, adequately treating the disease and preventing its recurrence.

RevDate: 2006-11-15
CmpDate: 1978-11-18

Bohonowych RO, Parks JL, RW Greene (1978)

Features of cystic calculi in cats in a hospital population.

Journal of the American Veterinary Medical Association, 173(3):301-303.

The case records of 131 cats undergoing surgery for cystic calculi at The Animal Medical Center during the period of June 1969 to January 1975 were reviewed. Data for 16 intact females, 63 spayed females, 14 intact males, and 38 castrated males were analyzed. The mean age of first occurrence was 4.9 years. Meaningful conclusions regarding breed predisposition could not be made. Phosphate calculi were the predominant (124/128 analyzed) type. Swab specimens were taken from the bladder wall at time of surgery in 86 cases; only 28 (32.8%) were positive for bacteria.

RevDate: 2013-11-21
CmpDate: 1979-02-23

Kaspar LV, Poole CM, WP Norris (1978)

Incidence of struvite urinary calculi in two ancestral lines of beagles.

Laboratory animal science, 28(5):545-550.

In the last 17 years, 55 of 2,125 (2.6%) purebred beagles maintained in a closed colony had urolithiasis. Males comprised 72.7% of the affected animals. All the uroliths except one set in the kidneys were in the urinary bladder, the urethra, or both. All uroliths were nearly pure magnesium ammonium phosphate hexahydrate. Partially inbred beagles had a 10.7% incidence of urolithiasis, compared to a 2.0% incidence in an outbred line.

RevDate: 2014-11-20
CmpDate: 1979-09-17

Boyarsky S, PC Labay (1978)

Glucagon, ureteral colic and ureteral peristalsis.

Transactions of the American Association of Genito-Urinary Surgeons, 70:22-24.

Experimentally, glucagon is an effective ureteral relaxant that induces a moderate diuresis. Our data suggest that in specified cases of ureteral colic, before the development of a ureteral bar, flaccid dilatation of the pelvis and renal shutdown, glucagon may facilitate the expulsion of small ureteral calculi. When the ureteral pain is due to hyperperistalsis the drug has promise in the alleviation of pain. The complexities of the pathophysiology of ureteral colic in an experimental model support the treatment of ureteral edema in colic with anti-inflammatory drugs but suggest certain precautions in the design of any investigation of drug therapy for colic, lest a good drug be found ineffective for the wrong reason-that it was used in an impossible situation.

RevDate: 2015-11-19
CmpDate: 1976-06-02

Kronfeld DS (1976)

Canine and feline nutrition. Part 3, minerals and other nutrients.

Modern veterinary practice, 57(3):176-180.

RevDate: 2019-10-28
CmpDate: 1976-10-20

Scott RC (1976)

Feline urologic diseases.

The Veterinary clinics of North America, 6(3):479-493.

RevDate: 2015-11-19
CmpDate: 1975-05-21

Rothe R, Esenberger F, Pfeifer KJ, et al (1975)

[Value of sequential scintrigraphy and clearance determination following normo- and hypothermic renal ischemia].

Nuclear-Medizin, 13(4):288-302.

Using quantitative sequential camera scintigraphy and simultaneous separated clearance determinations with 131-I-Hippuran and 169-Yb-EDTA renal function was measured applying a new surgical method which permits in-situ kidney perfusion and cooling in animals and patients. While mongrel dogs of 15 kg average weight (control group of N = 5) showed after 1 hour of normothermic ischaemia a postoperative delay of intrarenal transport of 131-I-Hippuran with reduction of 131-I-Hippuran and 169Yb-EDTA clearances, renal function returned to normal on the first postoperative day after 1-hour (N = 5) and 2-hour (N = 5) hypothermic ischaemia. In patients (N = 9) with hypothermic in-situ perfusion of between 40 and 92 min duration a transient postoperative delay of intrarenal 131-I-Hippuran transport and a reduction of the 131I-Hippuran clearance was observed which returned to almost normal 1 1/2 to 3 months after surgery. The results and the significance of the method discussed and are compared with clinical findings and with radiological and laboratory renal function studies.

RevDate: 2007-11-15
CmpDate: 1975-09-09

Nöske HD (1975)

[Renal parenchyma resection--development, technique, problems (author's transl)].

MMW, Munchener medizinische Wochenschrift, 117(19):817-822.

Organ preservation by renal surgery is the principal and most pressing task of urology, according to Bischoff. In clinical practice at the present time, resection of the renal parenchyma is the principal aim and is to a large extent achieved. Sacrificing a localised diseased portion of the parenchyma (organ amputation) contributes to the survival of the rest of the organ (preservation of the organ). The additional inevitable loss of functional tissue must be kept as small as possible (sparing the organ). Decisive syndromes are nephrolithiasis, renal tumors and to a decreasing extent, tuberculosis of the urinary system. The operation, which usually takes the form of resection of the pole of the kidney, but which must sometimes be extended to heminephrectomy and even more, repeatedly underlies attempts at improvement both in animal experiments and in the clinical sphere.

RevDate: 2018-12-03
CmpDate: 1976-03-30

Zimskind PD (1976)

Urology.

Surgery, gynecology & obstetrics, 142(2):227-229.

RevDate: 2013-11-21
CmpDate: 1976-07-06

Anonymous (1976)

Clinical and experimental studies on "general attack therapy" of ureteral stones.

Chinese medical journal, 2(1):25-32.

RevDate: 2003-11-14
CmpDate: 1977-05-25

Brodsky SL, Zimskind PD, Dure-Smith P, et al (1977)

Effects of crush and devascularizing injuries to the proximal ureter. An experimental study.

Investigative urology, 14(5):361-365.

Crush and devascularizing injuries were performed on proximal canine ureters. The pathogenesis of the reaction to these injuries was evaluated by using microbiologic, physiologic, radiologic, biophysical, histologic, and anatomic techniques. The results indicated that within 12 weeks after crush injuries lasting up to 60 min, renal function fully returned and radiologic demonstration of the crush area resolved, even through other radiologic and pathologic changes persisted in hte crushed ureters. The pathophsiologic results of devascularizing injuries that did not resolve spontaneously tended to progress more rapidly and case more serious renal impairment than any of the crush injuries. Devascularizing injuries that resolved tended to be benign in their effect.

RevDate: 2019-09-02
CmpDate: 1977-05-25

Pettersson S, Jonsson O, Sivertsson R, et al (1977)

Transurethral stone extraction with a vibrating basket catheter.

Scandinavian journal of urology and nephrology, 11(1):35-40.

In a recent in vitro study, mechanical vibration was shown to facilitate, considerably, both the passing of a basket catheter beyond an artificial ureteral stone as well as the extraction of a calculus. Therefore, a device by which vibration can be transmitted to the basket of a modified stone extractor was developed for clinical application. The basket moves to and fro with an amplitude of 2-4 mm and a frequency of 40-60 Hz. An experimental follow-up study was performed in dogs to find out whether the vibration procedure as such induced injuries to the ureters. Modified stone extractors were passed up bilaterally into the ureters of 11 dogs. Vibration was applied in a standardized manner to one side, the other non-vibrated side served as a control. Postoperatively, 5 dogs were followed during 4-5 weeks with repeated urographies. Specimens of the ureters were examined microscopically when the dogs were sacrificed. No complications which could be ascribed to the vibration procedure as such were observed. The vibration technique was tried also in a pilot study comprising 14 patients with distal ureteral stones; in 9 patients, the stones were successfully extracted. Of the remaining 5 patients in whom the stone extraction failed, 3 passed the stone spontaneously and in 2 ureterolithotomies were performed. No complications were encountered.

RevDate: 2006-11-15
CmpDate: 1977-05-12

Chaussy C, Eisenberger F, K Wanner (1977)

[The implantation of human kidney stones--a simple experimental model (author's transl)].

Der Urologe. Ausg. A, 16(1):35-38.

Human kidney stones of different chemical components were implanted into the renal pelvis of 15 mongrel dogs. In the first surgical intervention the ureter was ligated near the bladder. Eight days later a second laparotomy was performed. It was possible to implant concrements with a diameter of about 1 - 1.5 cm into the dilated pelvis. At the same time urinary stasis was removed by a neoureterostomy. This method offers a unique experimental model for the evaluation of problems involved in litholysis of human kidney stones by chemical and physical methods.

RevDate: 2016-11-23
CmpDate: 1977-07-23

Taneja OP, Balasubramanian S, Mittal KP, et al (1977)

The causation of ureteric reflux in vesical calculus --an experimental study.

The Indian journal of medical research, 65(1):117-124.

RevDate: 2018-11-13
CmpDate: 1977-07-18

Lian JB, Prien EL, Glimcher MJ, et al (1977)

The presence of protein-bound gamma-carboxyglutamic acid in calcium-containing renal calculi.

The Journal of clinical investigation, 59(6):1151-1157.

The amino acid gamma-carboxyglutamic acid (Gla) is found in four blood-clotting proteins, in a bone protein, in kidney protein, and in the protein present in various ectopic calcifications. This paper reports the presence of Gla in the EDTA-soluble, nondialyzable proteins of calcium-containing renal calculi including calcium oxalate, hydroxyapatite, and mixed stores of apatite and struvite (MgNH4PO4). Calculi composed of pure struvite and those composed of only uric acid or cystine do not contain Gla. From calcium oxalate and hydroxyapatite stontes, a protein of about 17,000 daltons was obtained which contained about 40 residues of Gla per 1,000 amino acids. The amino acid composition of this protein had no apparent relationship to the Gla-containing bone protein or to the similarly-sized F1 fragment of prothrombin which contains about 64 residues of Gla per 1,000 amino acid residues. The Gla-rich protein in calcium-containing renal stones thus may be a different Gla-containing protein. These data as well as other studies demonstrating the presence of Gla in pathologically calcified tissues not normally containing Gla suggest that the Gla-containing proteins may be of considerable pathophysiological significance.

RevDate: 2019-09-07
CmpDate: 1977-08-25

Walker AD, Weaver AD, Anderson RS, et al (1977)

An epidemiological survey of the feline urological syndrome.

The Journal of small animal practice, 18(4):283-301.

RevDate: 2019-08-27
CmpDate: 1977-10-14

Gonick HC (1977)

Kidney in patients with abnormalities in uric acid metabolism.

Contributions to nephrology, 7:79-96.

RevDate: 2019-07-27
CmpDate: 1977-12-29

Kubo T, Sasaki S, Numasato S, et al (1977)

Changes of the ureteral movement in diuretic condition and after ureteral surgery.

The Tohoku journal of experimental medicine, 123(1):9-22.

RevDate: 2003-11-14
CmpDate: 1976-10-01

Willeberg P, WA Priester (1976)

Feline urological syndrome: associations with some time, space, and individual patient factors.

American journal of veterinary research, 37(8):975-978.

In the Veterinary Medical Data Program, 4,111 cases of the feline urological syndrome (FUS) were identified from the abstracted records for the period March, 1964, through December, 1973. Associations between FUS and some relevant factors were evaluated by a relative risk technique, referring to the characteristics of the population of all cats seen at the 13 contributing veterinary colleges. Significant differences existed in the rates of FUS for these institutions, whereas the seasonal variations in general were similar for all institutions and years, showing a peak in March and a decrease in July-August. There was an increase in the frequency of the FUS diagnosis over the 10-year period. Persian cats showed increased risk, and Siamese cats decreased risk relative to the other breeds, and castrated males and spayed females were found to have excess risk when compared with their respective unaltered sex category; interaction from age affected the degree but not the direction of these associations. The age factor per se had risks peaking at 2 to 6 years. Finally, heavy cats showed significantly higher risk of FUS than did less heavy cats.

RevDate: 2006-11-15
CmpDate: 1976-10-20

Johnson TC (1976)

Surgical correction of ectopic ureter in the dog.

Journal of the American Veterinary Medical Association, 169(3):316-317.

RevDate: 2019-10-28
CmpDate: 1976-10-20

Collins DR (1976)

Dietary consideration in feline practice.

The Veterinary clinics of North America, 6(3):341-352.

RevDate: 2009-11-11
CmpDate: 1976-12-03

Sokratov NV, VP Skipetrov (1976)

[Possible role of blood coagulation factors in the etiology of urolithiasis].

Urologiia i nefrologiia.

RevDate: 2019-09-07
CmpDate: 1976-12-30

Clark WT (1976)

The structure of canine urinary calculi.

The Journal of small animal practice, 17(9):575-581.

RevDate: 2008-11-21
CmpDate: 1977-01-29

Bissada NK, Welch LT, JF Redman (1976)

Rapid formation of a staghorn calculus in the canine kidney. A surgical model.

Investigative urology, 14(3):246-248.

A model for immediate production of staghorn calculi in dogs is described. A paste made of gray investment is injected into the renal pelvis and allowed to solidify for 30 min. Calculi thus formed have a striking similarity to naturally occurring staghorn calculi and can be utilized by urology teaching programs to initiate residents in the technique of anatrophic nephrolithotomy.

RevDate: 2003-11-14
CmpDate: 1977-04-01

Muradian KM (1976)

[Electromyographic study of ureteral motor function in the presence of stones in the renal pelvis and different parts of the ureter].

Zhurnal eksperimental'noi i klinicheskoi meditsiny, 16(4):82-86.

RevDate: 2003-11-14
CmpDate: 1975-06-18

Wolff EF (1975)

Surgical relief for urethral obstruction due to sabulous calculi in the male cat.

Veterinary medicine, small animal clinician : VM, SAC, 70(1):73-75.

RevDate: 2003-11-14
CmpDate: 1975-09-13

Tillie JE, JE Benson (1975)

Phosphate uroliths in a Dachshund.

Veterinary medicine, small animal clinician : VM, SAC, 70(6):683.

RevDate: 2003-11-14
CmpDate: 1977-04-30

Pollock S, BM Wagner (1976)

Renal calculi in a dog. A four-year clinical picture.

Veterinary medicine, small animal clinician : VM, SAC, 71(12):1693-1696.

RevDate: 2003-11-14
CmpDate: 1975-05-10

Biewenga WJ (1975)

Preputial urethroplasty for relief of urethral obstruction in the male cat.

Journal of the American Veterinary Medical Association, 166(5):460-462.

RevDate: 2019-07-13
CmpDate: 1975-07-23

Taylor JS (1975)

Kidney cooling in partial nephrectomy. Evaluation of a technique.

Urology, 5(4):456-460.

A technique of cooling the isolated human kidney by immersing it in a plastic bag filled with iced saline slush is described. This technique is simple, swift to perform, requires no specialized equipment, and is inexpensive; it has proved to be effective and safe.

RevDate: 2006-11-15
CmpDate: 1975-11-22

Madewell BR, Creed JE, JB Hopkins (1975)

Hydronephrosis and pyelonephritis in a dog.

Journal of the American Veterinary Medical Association, 167(5):377-379.

RevDate: 2019-10-28
CmpDate: 1975-12-04

Grier RL (1975)

Symposium on surgical techniques in small animal practice. Cystotomy.

The Veterinary clinics of North America, 5(3):415-420.

RevDate: 2019-07-13
CmpDate: 1976-03-01

Scott R (1975)

Urinary tract stone disease. Classic studies.

Urology, 6(6):667-675.

RevDate: 2003-11-14
CmpDate: 1975-04-16

Anonymous (1975)

Urolithiasis in cats.

Modern veterinary practice, 56(1):61-63.

RevDate: 2018-12-03
CmpDate: 1975-05-10

Gershoff SN (1975)

Nutritional problems of household cats.

Journal of the American Veterinary Medical Association, 166(5):455-458.

RevDate: 2019-06-21
CmpDate: 1975-05-28

Raney AM (1975)

Electrohydraulic lithotripsy: experimental study and case reports with the stone disintegrator.

The Journal of urology, 113(3):345-347.

Electrohydraulic lithotripsy with the SD-1 for crushing bladder stones was performed experimentally, in vitro and in vivo. The results of this experiment in laboratory animals and in 19 patients revealed that the procedure is safe and superior to the conventional methods with blind or optical lithotriptors. The methods is easy to learn and application of the technique may be combined in the same session with other urological operations. This procedure was done more than 50 times in toto without any complication.

RevDate: 2019-07-13
CmpDate: 1975-05-27

Griffith DP, DM Musher (1975)

Acetohydroxamic acid. Potential use in urinary infection caused by urea-splitting bacteria.

Urology, 05(3):299-302.

Several lines of evidence suggest that bacterial urease is the primary cause of infection-induced urinary stones. The hydroxamate group of compounds are specific urease inhibitors. Of the cogeners studied, to dat, AHA (acetohydroxamic acid) appears to have the most pharmacologic potential. AHA is rapidly and completely absorbed from the gastrointestinal tract and is concentrated and excreted in the urine. In animals it appears to be relatively nontoxic. Although its toxicity in human beings has not been studied, its similarity to hydroxyurea suggests that reversible toxicity involving the gastrointestinal tract and the hematopoietic systems may result when high doses are administered. The only known metabolite of AHA is acetamide which is nontoxic and rapidly excreted in the urine. Pharmacologic use of AHA is expected to be practical and relatively safe. Use of AHA in patients with urinary infections caused by urea-splitting bacteria may reduce pathogenicity of the infecting organism and may lead to prevention and/or dissolution of stones commonly associated with such infections.

RevDate: 2019-07-02
CmpDate: 1975-07-28

Anonymous (1975)

Editorial:: Fat lazy cats and FUS.

The Veterinary record, 96(14):297-298.

RevDate: 2016-11-23
CmpDate: 1975-09-24

Zontine WJ (1975)

Radiographic interpretation. The urethra.

Modern veterinary practice, 56(6):411-415.

RevDate: 2006-11-15
CmpDate: 1975-09-22

Alvarenga J, Spicciati W, M Iwasaki (1975)

Surgical removal of multiple urinary calculi.

Modern veterinary practice, 56(7):481.

RevDate: 2003-11-14
CmpDate: 1975-10-03

Anonymous (1975)

New technics recommendations.

Modern veterinary practice, 56(8):583-585.

RevDate: 2003-11-14
CmpDate: 1975-12-04

Gourley IM (1975)

Symposium on surgical techniques in small animal practice. Nephrectomy and nephrolithotomy.

The Veterinary clinics of North America, 5(3):401-413.

RevDate: 2016-11-23
CmpDate: 1975-12-12

Van Gastel-Jansen A (1975)

[Pneumocystography in the dog (author's transl)].

Tijdschrift voor diergeneeskunde, 100(9):507-508.

RevDate: 2019-08-17
CmpDate: 1975-11-05

Kumagai I (1975)

[A scanning electron microscopic study on the urotheliums. I. Ultrastructure of the urothelial surface of the bladder (author's transl)].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 66(3):131-139.

RevDate: 2013-11-21
CmpDate: 1975-12-20

Anonymous (1975)

Spraying by castrated tomcats.

Modern veterinary practice, 56(10):729-731.

RevDate: 2019-07-13
CmpDate: 1975-12-23

Raney AM, J Handler (1975)

Electrohydraulic nephrolithotripsy.

Urology, 6(4):439-442.

RevDate: 2016-11-23
CmpDate: 1976-01-26

Zontine WJ (1975)

Urolithiasis.

Modern veterinary practice, 56(11):776-780.

RevDate: 2016-11-23
CmpDate: 1976-02-13

Zontine WJ (1975)

The urinary system.

Modern veterinary practice, 56(12):840-844.

RevDate: 2016-11-23
CmpDate: 1976-03-24

Farrow CS, WJ Zontine (1976)

Urinary problems.

Modern veterinary practice, 57(1):42-45.

RevDate: 2013-11-21
CmpDate: 1976-08-02

Bartone FF, Shervey PD, PJ Gardner (1976)

Long term tissue responses to catgut and collagen sutures.

Investigative urology, 13(6):390-394.

Reaction of catgut and collagen sutures in both wounded and nonwounded bladder, kidney, muscle, and liver tissue was studied in guinea pigs up to 130 days after implantation. A minimal amount of degradation of ths so-called absorbable sutures was observed. There was little difference in absorption rates in the tissues studied although there seemed to be slightly greater absorption in the kidney than in other tissues. Tissue responses were characterized by the formation of a bilaminar connective tissue capsule. The inner zone contained primarily fibroblasts and histiocytes, while lymphocytes, neutrophils, and eosinophils were scattered throughout both layers. Multinucleated giant cells were often observed in the inner layer, and aggregates of lymphocytes and mast cells were occasionally found in the pericapsular areas. Calculi formed on those suture loops that were loosely tied and thus projected into the bladder lumen.

RevDate: 2006-11-15
CmpDate: 1992-07-27

Clark TP, R Panciera (1992)

Calcium phosphate urolithiasis and renal dysplasia in a young dog.

Journal of the American Veterinary Medical Association, 200(10):1509-1511.

Calcium phosphate urolithiasis and bilateral renal dysplasia was diagnosed in an 8-week-old Border Terrier with a history of urine dribbling, which had been observed from the time of birth. Most reported cases of calcium phosphate urolithiasis are secondary to hypercalcemic disorders, but this was not detected. In addition, despite renal dysplasia, there was no evidence of renal failure. After cystotomy and calculus removal, the dog has remained clinically normal.

RevDate: 2019-07-02
CmpDate: 1992-08-11

Shearer AG, AS Nash (1992)

Oxalate urolithiasis in Dandie Dinmont terriers.

The Veterinary record, 130(21):480.

RevDate: 2019-10-21
CmpDate: 1992-08-11

McCarthy RJ, Lipowitz AJ, TD O'Brien (1992)

Continent jejunal reservoir (Kock pouch) for urinary diversion in dogs.

Veterinary surgery : VS, 21(3):208-216.

Urinary diversion by transplantation of both ureters into a reservoir constructed from 60 cm of jejunum was performed in six clinically normal dogs. The reservoir was connected to a stoma on the abdominal wall through a valve constructed from a short segment of intussuscepted bowel to provide continence. The reservoir was emptied three times daily by catheterization. One dog did not survive the surgical procedure and two dogs died within 1 week of surgical complications. The postoperative capacity of the reservoir in surviving dogs was 100 to 200 mL; it increased during the first month to 600 to 750 mL. Continence was excellent in two dogs. One dog was continent until month 2, when partial slippage of the intussusception occurred. A reversible hyponatremic, hypochloremic, hypokalemic metabolic acidosis developed. Bacteriuria was not responsive to systemic or local instillation of antibiotics. Ascending pyelonephritis, hydroureter, and hydronephrosis occurred in two dogs. Struvite urinary calculi formed in one dog. The procedure as described would be unsuitable for clinical use in dogs.

RevDate: 2006-11-15
CmpDate: 1992-09-09

Lulich JP, CA Osborne (1992)

Catheter-assisted retrieval of urocystoliths from dogs and cats.

Journal of the American Veterinary Medical Association, 201(1):111-113.

To facilitate medical dissolution of uroliths in dogs and cats, urinary catheters may be used to retrieve urocystoliths for quantitative mineral analysis. Following transurethral catheterization of the urinary bladder and distention of the bladder with physiologic saline solution, urine and saline solution are aspirated into a syringe while an assistant vigorously and repeatedly moves the abdomen up and down. Dispersion of small uroliths throughout fluid in the bladder lumen facilitates their aspiration into the catheter and syringe.

RevDate: 2013-11-21
CmpDate: 1992-09-09

Case LC, Ling GV, Franti CE, et al (1992)

Cystine-containing urinary calculi in dogs: 102 cases (1981-1989).

Journal of the American Veterinary Medical Association, 201(1):129-133.

One hundred and seven cystine-containing urinary calculi from 1 female and 101 male dogs were analyzed. Cystine-containing calculi accounted for 2% (107 of 5,375) of all canine urinary calculi submitted to the urinary stone analysis laboratory from July 1981 through December 1989. Male dogs that formed cystine calculi were compared with 3 other canine populations to determine whether certain breeds were apparently at increased or decreased risk for cystine calculus formation. In one or more of 3 population comparisons, significantly increased risk of cystine calculus formation was found in Mastiffs, Australian Cattle Dogs, English Bulldogs, Chihuahuas, Bullmastiffs, Newfoundlands, Dachshunds, Basenjis, Australian Shepherd Dogs, Scottish Deerhounds, Staffordshire Terriers, Miniature Pinschers, pitbull terriers, Welsh Corgis, Silky Terriers, and Bichon Frises. Significantly low risk of cystine calculus formation was found in German Shepherd Dogs, Poodles, Schnauzers, and mixed-breed dogs.

RevDate: 2006-11-15
CmpDate: 1991-10-17

Kruger JM, Osborne CA, Goyal SM, et al (1991)

Clinical evaluation of cats with lower urinary tract disease.

Journal of the American Veterinary Medical Association, 199(2):211-216.

In a prospective study, 141 cats with hematuria, dysuria, urethral obstruction, or combinations of these signs were evaluated by contemporary diagnostic methods and compared with 26 clinically normal cats (controls). Specific diagnosis was established in 45% (64/141) of cats affected with lower urinary tract disease (LUTD). Crystalline matrix plug-induced urethral obstruction was diagnosed in 21% (30/141) of affected cats, uroliths were identified in 21% (30/141) of affected cats, uroliths with concomitant bacterial urinary tract infection (UTI) were identified in less than 2% (2/141) of affected cats, and bacterial UTI alone was identified in less than 2% (2/141) of cats with LUTD. Viruses, mycoplasmas, and ureaplasmas were not isolated from urine samples collected from affected or control cats. Bovine herpesvirus 4 (BHV-4)-neutralizing antibodies were not detected in any serum sample obtained from cats with LUTD or from control cats. In contrast, BHV-4 antibodies were detected by an indirect immunofluorescent antibody (IFA) test in sera obtained from 31% (44/141) of cats with LUTD and 23% (6/26) of control cats. The prevalence of positive BHV-4 IFA test results in affected cats was not significantly different from that observed in control cats. Significant association was not apparent between positive BHV-4 IFA test results and clinical diagnosis, abnormal laboratory findings, or cat age. However, the number of male cats with BHV-4 IFA titer was significantly (P less than 0.02, chi 2 test) greater than that of female cats. Detection of BHV-4 antibodies in approximately 30% of affected and control cats indicates prior virus exposure. Further investigations are warranted to clarify the specific role of BHV-4 in cats with naturally acquired LUTD.

RevDate: 2007-11-15
CmpDate: 1991-12-17

Weissmüller J, Schafhauser W, Schrott KM, et al (1991)

[Laser lithotripsy of ureteral stones. Personal experiences].

Der Urologe. Ausg. A, 30(5):333-336.

The in vitro evaluation of a pulsed Nd:YAG laser, showed an effective and fine fragmentation of urinary calculi and showed only minimal subepithelial bleeding in the directly irradiated canine ureter. Since 1989 we have treated ureteral calculi in 30 patients. The laser pulses of 15-20 mJ (at fiber tip), 20 ns, 20-25 cps are transmitted by a 300-microns quartz fiber with a specially formed tip focusing the light. The fiber is passed through an 11.5-F ureteroscope within a guide tube, or, without a guide tube, through one of the new minimized ureteroscopies and is placed in front of the calculus. In 27 patients the procedure was successful, without any residual concretions after 1 day. In our opinion the advantages of this method are the very fine-grained, complete fragmentation of all sorts of calculi, the highly atraumatic procedure, and the absence of either optical or acoustic irritation to the operator.

RevDate: 2013-11-21
CmpDate: 1992-02-14

Lulich JP, Osborne CA, Unger LK, et al (1991)

Prevalence of calcium oxalate uroliths in miniature schnauzers.

American journal of veterinary research, 52(10):1579-1582.

Epidemiologic data were evaluated from all dogs admitted to the University of Minnesota, Veterinary Teaching Hospital (UMVTH) between June 1981 and November 1989. Of 69,890 admissions, 2,077 were Miniature Schnauzers. Uroliths were retrieved from 63 of the 2,077 Miniature Schnauzers admitted. In 20 of the 63 urolith episodes, calcium oxalate was the predominant mineral identified. By comparison, calcium oxalate uroliths were identified in only 56 of the remaining 67,813 non-Miniature Schnauzer canine admissions. The odds that uroliths from Miniature Schnauzers were composed of calcium oxalate was 11.8 times greater than for other canine breeds evaluated at the UMVTH (95% confidence interval = 6.8 to 20.1). Data also were evaluated from files of uroliths retrieved from dogs and submitted to the Minnesota Urolith Center for quantitative mineral analysis, between June 1981 and November 1989. Of 3,930 uroliths analyzed, 615 (15.6%) uroliths were obtained from Miniature Schnauzers. of the 615 uroliths, 175 (28.4%) were calcium oxalate. By comparison, only 550 (16.6%) of the remaining 3,315 from dogs of breeds other than Miniature Schnauzers were calcium oxalate. The odds that uroliths submitted for analysis were composed of calcium oxalate was 2 times greater for Miniature Schnauzers than for dogs of other breeds (95% confidence interval = 1.6 to 2.4). Calcium oxalate uroliths were retrieved more frequently in males than females. The risk for males developing calcium oxalate uroliths was greater than 3 times the risk for females in both groups of data evaluated. The mean age of all Miniature Schnauzers admitted to the UMVTH with calcium oxalate uroliths was 9 years. Calcium oxalate uroliths were not detected in Miniature Schnauzers younger than 1.7 years.

RevDate: 2013-11-21
CmpDate: 1992-02-14

Lulich JP, Osborne CA, Nagode LA, et al (1991)

Evaluation of urine and serum metabolites in miniature schnauzers with calcium oxalate urolithiasis.

American journal of veterinary research, 52(10):1583-1590.

To evaluate underlying causes of calcium oxalate urolithiasis, 24-hour excretion of urine metabolites was measured in 6 Miniature Schnauzers that formed calcium oxalate (CaOx) uroliths during periods when they were fed a standard diet and during periods when food was withheld. Serum concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D also were evaluated. Serum calcium concentrations were normal in all 6 affected Miniature Schnauzers; however, during diet consumption, mean 24-hour urinary excretion of calcium was significantly (P = 0.025) higher than calcium excretion when food was withheld. In 1 dog, urinary calcium excretion was lower during the period of food consumption, compared with the period when food was withheld. Compared with clinically normal Beagles, Miniature Schnauzers that formed CaOx uroliths excreted significantly greater quantities of calcium when food was consumed (P = 0.0004) and when food was withheld (P = 0.001). Miniature Schnauzers that formed CaOx uroliths excreted significantly less oxalate than clinically normal Beagles during fed (P = 0.028) and nonfed (P = 0.004) conditions. Affected Miniature Schnauzers also excreted abnormally high quantities of uric acid. Excretion of citrate was not different between Miniature Schnauzers with CaOx urolithiasis and clinically normal Beagles. In 5 of 6 Miniature Schnauzers with CaOx urolithiasis, concentrations of serum parathyroid hormone were similar to values from age- and gender-matched Miniature Schnauzers without uroliths. The concentration of serum parathyroid hormone in 1 dog was greater than 4 times the mean concentration of clinically normal Miniature Schnauzers. Mean serum concentrations of 1,25-dihydroxyvitamin D in Miniature Schnauzers with calcium oxalate urolithiasis were similar to concentrations of clinically normal Miniature Schnauzers.

RevDate: 2013-11-21
CmpDate: 1991-09-24

Ling GV, Ruby AL, Harrold DR, et al (1991)

Xanthine-containing urinary calculi in dogs given allopurinol.

Journal of the American Veterinary Medical Association, 198(11):1935-1940.

Clinical features and laboratory findings were evaluated in 10 dogs that formed xanthine-containing urinary calculi during the period that they were given allopurinol (9 to 38 mg/kg of body weight/d). Duration of allopurinol treatment was 5 weeks to 6 years. Of the 10 dogs, 9 (all Dalmatians) had formed uric acid-containing calculi at least once before allopurinol treatment was initiated. It was not possible to recognize xanthine as a crystalline component of the calculi by use of a chemical colorimetric method or by polarized light microscopy. We concluded that the best diagnostic method for recognition of xanthine-containing calculi was high-pressure liquid chromatography because it is quantitative, sensitive, and accurate, and can be conducted on a small amount (1 to 2 mg) of crystalline material.

RevDate: 2018-11-13
CmpDate: 1991-10-09

Escolar E, Bellanato J, M Rodriquez (1991)

Study of cystine urinary calculi in dogs.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 55(1):67-70.

The composition and structure of 48 canine cystine urinary stones were determined by infrared spectroscopy, scanning electron microscopy and electron dispersive X-ray analysis. The infrared analysis showed that about 45% of the specimens were composed of pure cystine. The remainder also contained calcium oxalate (mono and/or dihydrate), magnesium ammonium phosphate hexadydrate (struvite), calcium hydrogen phosphate dihydrate (brushite) and complex urates (ammonium, ammonium potassium and/or potassium enriched ammonium urate). The infrared study of several samples heated at 620 degrees C and 750 degrees C revealed the presence of apatitic calcium phosphate. This compound was difficult to detect in the spectrum of the original samples due to the small proportion of phosphate contained in the calculi and to band overlapping. The examination of a series of selected samples by means of scanning electron microscopy and energy dispersive X-ray analysis complemented the infrared results.

RevDate: 2016-11-23
CmpDate: 1991-01-23

Goldberg BB, Bagley D, Liu JB, et al (1991)

Endoluminal sonography of the urinary tract: preliminary observations.

AJR. American journal of roentgenology, 156(1):99-103.

Endoluminal sonography of the urinary tract was performed by using endoluminal ultrasound transducers contained within 2-mm-diameter catheters. The catheters were inserted into the urinary bladder via the urethra and advanced into the ureters and renal pelvis under cystoscopic control; then, cross-sectional images of the bladder, ureters, and renal pelvis were obtained. Two dogs and seven human patients were studied. In one dog, a 4.5-mm pseudopolyp, which was surgically created in the bladder wall, was successfully imaged; in the other, stones 2 mm or larger inserted into the bladder were identified. Of the seven patients, sonography showed stones embedded in the renal parenchyma (one patient) and the mucosa of the distal ureter (one patient). These were ultimately confirmed by their eventual removal. In a third, sonography showed a tumor of the distal ureter and identified the depth of the tumor. This was confirmed by biopsy. In a fourth, sonography clearly showed a crossing vessel as the cause for narrowing of the proximal ureter. In a fifth, sonography showed that the cause of a ureteral stricture was idiopathic. In the last two cases, sonography did not reveal a cause for hematuria. In these last three cases, negative sonographic results were confirmed by direct ureteroscopic examinations and follow-up studies. Our observations based on this limited study suggest that endoluminal sonography is a useful procedure for diagnosing diseases of the urinary tract. Further study is warranted.

RevDate: 2019-09-12
CmpDate: 1991-11-07

Oosterlinck W, Verbeeck R, Cuvelier C, et al (1991)

Toxicity of litholytic ethylenediaminetetraacetic acid solutions to the urothelium of the rat and dog.

Urological research, 19(4):265-268.

The toxicity to the urothelium of bipotassium ethylene-diaminetetraacetic acid (K2-EDTA) buffered with 0.2 M triethanolamine (TEA) at pH 8 and 8.5 was tested in rats and dogs. Even at a low concentration of 3.125 mM, K2-EDTA is very noxious to the bladder mucosa. This toxicity is not due to the buffer TEA, which is well tolerated. Although buffered K2-EDTA, at pH 8.5 is an excellent chemolytic agent for calcium-containing stones, its clinical use is limited by this toxicity.

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RJR Experience and Expertise

Researcher

Robbins holds BS, MS, and PhD degrees in the life sciences. He served as a tenured faculty member in the Zoology and Biological Science departments at Michigan State University. He is currently exploring the intersection between genomics, microbial ecology, and biodiversity — an area that promises to transform our understanding of the biosphere.

Educator

Robbins has extensive experience in college-level education: At MSU he taught introductory biology, genetics, and population genetics. At JHU, he was an instructor for a special course on biological database design. At FHCRC, he team-taught a graduate-level course on the history of genetics. At Bellevue College he taught medical informatics.

Administrator

Robbins has been involved in science administration at both the federal and the institutional levels. At NSF he was a program officer for database activities in the life sciences, at DOE he was a program officer for information infrastructure in the human genome project. At the Fred Hutchinson Cancer Research Center, he served as a vice president for fifteen years.

Technologist

Robbins has been involved with information technology since writing his first Fortran program as a college student. At NSF he was the first program officer for database activities in the life sciences. At JHU he held an appointment in the CS department and served as director of the informatics core for the Genome Data Base. At the FHCRC he was VP for Information Technology.

Publisher

While still at Michigan State, Robbins started his first publishing venture, founding a small company that addressed the short-run publishing needs of instructors in very large undergraduate classes. For more than 20 years, Robbins has been operating The Electronic Scholarly Publishing Project, a web site dedicated to the digital publishing of critical works in science, especially classical genetics.

Speaker

Robbins is well-known for his speaking abilities and is often called upon to provide keynote or plenary addresses at international meetings. For example, in July, 2012, he gave a well-received keynote address at the Global Biodiversity Informatics Congress, sponsored by GBIF and held in Copenhagen. The slides from that talk can be seen HERE.

Facilitator

Robbins is a skilled meeting facilitator. He prefers a participatory approach, with part of the meeting involving dynamic breakout groups, created by the participants in real time: (1) individuals propose breakout groups; (2) everyone signs up for one (or more) groups; (3) the groups with the most interested parties then meet, with reports from each group presented and discussed in a subsequent plenary session.

Designer

Robbins has been engaged with photography and design since the 1960s, when he worked for a professional photography laboratory. He now prefers digital photography and tools for their precision and reproducibility. He designed his first web site more than 20 years ago and he personally designed and implemented this web site. He engages in graphic design as a hobby.

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Urolithioasis is a surprising common problem in make dogs and cats. An undiagnosed and untreated acute attach involving urethral blockage causes severe pain and can be lethal within dats. Complete obstruction causes uremia within 36–48 hr, which leads to depression, anorexia, vomiting, diarrhea, dehydration, coma, and death within ~72 hr. Urethral obstruction is an emergency condition, and treatment should begin immediately. Familiarity with the problem and its symptoms could save your pet's life. I know, because it saved mine: One of my long-term pets—a cat named Leonard—struggled with urolithiasis most of his life. For many years, it was possible to control the problem with dietary medications. Ultimately, however, he required surgery, which was a success and allowed his to live into a comfortable old age. R. Robbins

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Collection of publications by R J Robbins

Reprints and preprints of publications, slide presentations, instructional materials, and data compilations written or prepared by Robert Robbins. Most papers deal with computational biology, genome informatics, using information technology to support biomedical research, and related matters.

Research Gate page for R J Robbins

ResearchGate is a social networking site for scientists and researchers to share papers, ask and answer questions, and find collaborators. According to a study by Nature and an article in Times Higher Education , it is the largest academic social network in terms of active users.

Curriculum Vitae for R J Robbins

short personal version

Curriculum Vitae for R J Robbins

long standard version

RJR Picks from Around the Web (updated 11 MAY 2018 )